Heart Stem Cell Trial: Interview With Researcher Roberto Bolli, MD

Heart Stem Cell Study: Researcher’s Perspective

University of Louisville cardiologist Roberto Bolli, MD, led the stem cell study that tested using patients’ own heart stem cells to help their hearts recover from heart failure. Though that trial was preliminary, the results look promising — and may one day lead to a cure for heart failure.  


Here, Bolli talks about what this work means and when it might become an option for patients.

Understanding Stem Cells

How long until this becomes available?

“Realistically, this will not come… for another three or four years, at least,” Bolli says. “It may be longer, depending on the results of the next trial, of course.”

Larger studies are needed to confirm the procedure’s safety and effectiveness. If those succeed, it could be “the biggest advance in cardiovascular medicine in my lifetime,” Bolli says.

How are the other patients in the first trial doing?

A total of 20 patients took part in the initial study.

All of them experienced significant improvement in their heart failure and now function better in daily life, according to Bolli. “The patients can do more, there’s more ability to exercise, and the quality of life improves markedly,” Bolli says.

Bolli’s team published its findings on how the patients were doing one year after stem cell treatment in November 2011 in the Lancet, a British medical journal.

Each patient was infused with about 1 million of his or her own cardiac stem cells, which could eventually produce an estimated 4 trillion new cardiac cells, Bolli says. His team plans to follow each patient for two years after their stem cell procedure.

Keep in mind that this was a phase I study. Those focus on safety more than effectiveness.

How does this compare to other stem cell trials?

The results were “much more striking” than past stem cell trials to heal the heart, Bolli says.

This trial was the first in the world to use stem cells derived from the heart. Earlier studies used stem cells gleaned from different bodily sources, including bone marrow, adipose (fat) tissue, and circulating blood. Those showed either no improvement or only modest gains in a patient’s left ventricular ejection fraction, a measure of the heart’s pumping ability.

In contrast, one year after being injected with their own heart stem cells, Bolli’s patients gained an average increase of 10 percentage points in ejection fraction.

For example, a patient with a baseline ejection fraction of 30% would have increased to 40%, he says.

“That is huge when you consider that previous studies of stem cells in these kinds of patients — patients with ischemic heart failure — have reported improvements of three, four, five [percentage] points in ejection fraction,” Bolli says.

Also, in Bolli’s patients, cardiac tissue scarred by heart attack had shrunk by an average of 50% one year after the experimental procedure.

GD Star Rating
loading...

From: http://www.webmd.com/heart/features/heart-stem-cell-study-roberto-bolli?src=RSS_PUBLIC

Leave a Reply

Your email address will not be published. Required fields are marked *

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>

Shopping Cart

There are no items in your cart.

Our Products

  • Credit Repair Guide

    120px-Credit-cards
    There are many misconceptions about credit scores out there. There are customers who believe that they don’t have a credit score and many customers who think that their credit scores just don’t really matter. These sorts of misconceptions can hurt your chances at some jobs, at good interest rates, and even your chances of getting More Info »
    $2.00$1.00
  • Do-It-Yourself Loan Modification Software Kit

    product_img_1_128x128
    The loan modification software guides the you the homeowner to the necessary calculations and forms that the banks are looking for, they are done for you instantly. You simply enter your information and the software does the rest. The software also integrates the new Obama home rescue program designed to give you homeowners a better More Info »
    $29.99$10.00
  • Free Short Sale e-Book

    Image_shortsale_book
    WARNING: Do not list your home as a Short Sale until you have read this totally FREE report. This eBook can help you to buy another home in as little as 12 months!
    $0.00
  • Lender Forms

    lender-forms
    An assorted collection of lender forms.
    $0.00

Categories

Archives

Advertisement

Advertisement

Call Now: 877-239-1878